Responsiveness of normal and transformed rat embryo cell cultures to poly I · poly C and interferon

✍ Scribed by Aaron E. Freeman; Carol P. Uhlendorf; Penny E. Younkers; Samuel Baron

• Book ID: 102879950
• Publisher: John Wiley and Sons
• Year: 1970
• Tongue: English
• Weight: 511 KB
• Volume: 76
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1040760314

✦ Synopsis

Abstract

A number of normal rat cell cultures as well as cultures transformed spontaneously, by chemicals, and/or by oncogenic viruses were tested for responsiveness to the interferon inducer polyinosinic·polycytidylic acid, or to exogenous interferon. Responsiveness, or lack thereof, had no correlation with subculture passage number, infection with RNA leukemia virus, morphological transformation by oncogenic RNA or DNA viruses, chemical treatment, or the ability of these cells to produce tumors in isologous host animals. The data indicate that lack of response to interferon or to the inducer is neither a necessary prerequisite nor an absolute result of cellular transformation of rat cells.