## Abstract This study reports on the evaluation of the Wilms tumor suppressor gene __WT1__ in 14 endometrial carcinomas. Despite the fact that several endometrial carcinomas were shown to express __WT1__, we were unable to demonstrate mutations in the __MT1__ zinc finger region, suggesting that __
Responsiveness of chemotherapy based on the histological type and Wilms’ tumor suppressor gene mutation in bilateral Wilms’ tumor
✍ Scribed by Rie Shibata; Ayako Takata; Akinori Hashiguchi; Akihiro Umezawa; Taketo Yamada; Jun-ichi Hata
- Book ID
- 114424643
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 207 KB
- Volume
- 53
- Category
- Article
- ISSN
- 1320-5463
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## Abstract The Wilms' tumor 1 gene, __WT1__, encodes a zinc‐finger protein that is implicated in the development of Wilms' tumor. Mutant or aberrantly expressed WT1 isoforms have also been described in desmoplastic small round cell tumor, acute leukemias, mesothelioma, breast tumors and melanoma.
The expression of the Wilms tumor suppressor gene WT1 is largely restricted to elements of the developing urogenital system. In the fetal kidney, WT1 transcripts are present at low levels in the condensing mesenchyme and at much higher levels in differentiating glomerular epithelium and are not dete