𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Responses of CD8+ T cells to intracellular bacteria

✍ Scribed by John T Harty; Michael J Bevan

Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
83 KB
Volume
11
Category
Article
ISSN
0952-7915

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✦ Synopsis

Recent studies of CD8 + T cell responses against intracellular bacteria have provided insights into the relevance of the exogenous and endogenous MHC class I presentation pathways during the priming and effector stages. The capacity of these organisms to deliver vaccine antigens, either as bacterial protein or as plasmid DNA expressed by host antigen-presenting cells, has been investigated. Ongoing studies of CD8 + T cell effector functions suggest the existence of novel pathways of resistance to bacterial infection. These results, together with advances in our understanding of nonclassical MHC class I presentation, reveal the impact of pathogen biology on host immunity to infection.

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