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Response of CD4+T Cells from Myasthenic Patients and Healthy Subjects of Biosynthetic and Synthetic Sequences of the Nicotinic Acetylcholine Receptor

✍ Scribed by B Diethelm-Okita; G.B Wells; A Kuryatov; D Okita; J Howard; J.M Lindstrom; B.M Conti-Fine


Book ID
115621555
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
274 KB
Volume
11
Category
Article
ISSN
0896-8411

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## Abstract The response of human T lymphocytes against the nicotinic acetylcholine receptor (AChR) was studied in five patients with myasthenia gravis (MG) and in six healthy donors using either native Torpedo AChR or recombinant protein derived from the mammalian AChR Ξ± subunit (X4, residues 6–21

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The a-subunit of the nicotinic acetylcholine receptor is the major target of the autoimmune response in myasthenia gravis. We investigated the proliferative response of T cells from patients with myasthenia gravis and healthy volunteers to recombinant polypeptides of the human acetylcholine receptor