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Resolution-recovery for EPR imaging of free radical molecules in mice

✍ Scribed by Yusuke Ikebata; Hideo Sato-Akaba; Takashi Aoyama; Hirotada Fujii; Kouichi Itoh; Hiroshi Hirata

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
541 KB
Volume
62
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

A method of post‐processing to enhance the image resolution of the distribution of free radical molecules obtained with continuous‐wave electron paramagnetic resonance (CW‐EPR) imaging is reported. The low spatial resolution of EPR imaging, which has created difficulties in biomedical applications, was overcome by the method of resolution‐recovery for EPR imaging. High spatial resolution images for the distribution of free radical molecules with a very short relaxation time were obtained with this method. The method's two‐step postprocessing consists of conventional deconvolution and filtered back‐projection and a process of iterative deconvolution. The resolution‐recovery method was demonstrated with three‐dimensional (3D) imaging of stable nitroxyl radicals in mouse head. In phantom experiments with a solution of triarylmethyl (TAM) radicals, the spatial resolution was improved by a factor of 7 with the resolution‐recovery method. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.

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