Slice-selective images of free radicals in mice with modulated field gradient electron paramagnetic resonance (EPR) imaging
✍ Scribed by Hideo Sato-Akaba; Haruhiko Abe; Hirotada Fujii; Hiroshi Hirata
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 486 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0740-3194
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✦ Synopsis
Abstract
Continuous wave (CW) electron paramagnetic resonance (EPR) imaging can be used to obtain slice‐selective images of free radicals without measuring three‐dimensional (3D) projection data. A method that incorporated a modulated magnetic field gradient (MFG) was combined with polar field gradients to select a slice in the subject noninvasively. The slice‐selective in vivo EPR imaging of triarylmethyl radicals in the heads of live mice is reported. 3D surface‐rendered images were successfully obtained from slice‐selective images. In the experiment in mice, a slice thickness of 1.8 mm was achieved. Magn Reson Med 59:885–890, 2008. © 2008 Wiley‐Liss, Inc.