Resolution of α-methyl amino esters by chymotrypsin
✍ Scribed by G.M. Anantharamaiah; Roger W. Roeske
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 139 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The aromatic-group specificity1 of a-chymotrypsin (o-CT) has been exploited for the re- solution of many racemic aromatic acids via hydrolysis of their esters. ## 2 - In contrast, virtually no attention has been paid to the possibility of resolving aliphatic acids by this procedure.
Racemic amino acids were resolved by lipase via hydrolysis of their esters. Lipases (Pseudomonas lipase from Amano PS, Rhizopus lipase from Serva, and porcine pancrease lipase from Sigma) could selectively hydrolyze the L-amino acid esters in aqueous solution with high reactivities and selectivities