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Resolution of the diastereomers of a large synthetic peptide by capillary electrophoresis using nonionic surfactants

✍ Scribed by Dr. Martin Gilges; Mark Hadley

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 512 KB
Volume: 18
Category: Article
ISSN: 0173-0835
DOI: 10.1002/elps.1150181536

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✦ Synopsis

Abstract

A capillary electrophoretic method was developed for the determination of the diastereomeric composition of the bradykinin B~2~ antagonist, SB‐238592‐DB. The nonionic surfactant Brij 35 was demonstrated to be suitable for the baseline resolution of the three diastereoisomers of SB‐238592‐DB in the presence of a low pH phosphate buffer and small volume percentages of acetonitrile.

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