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Resolution of some chiral mandelic acid derivatives into enantiomers by reversed-phase high-performance liquid chromatography via α- and β-cyclodextrin inclusion complexes

✍ Scribed by Janusz Debowski; Janusz Jurczak; Danuta Sybilska


Book ID
108335442
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
339 KB
Volume
282
Category
Article
ISSN
1873-3778

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Enantiomers of terfenadine were resolved by high-performance liquid chromatography (HF'LC) using a chiral stationary phase (CSP) column packed with p-cyclodextrin (p-CD) covalently bound to silica. Separation was achieved in both the reverse phase and normal phase modes. Resolution of enantiomers wa