✦ LIBER ✦

Resolution of Racemic N-Acyl-1-arylaminoalkanes on a (3,5-Dinitrobenzoyl)phenylglycinol-Derived High Performance Liquid Chromatography Chiral Stationary Phase

✍ Scribed by Jae Jeong Ryoo; Sung Hyun Im; Kwang-Pill Lee; Jung Hag Park; Myung Ho Hyun

Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 45 KB
Volume: 63
Category: Article
ISSN: 0026-265X
DOI: 10.1006/mchj.1999.1774

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✦ Synopsis

A chiral stationary phase (CSP 2) was prepared by connecting N-(3,5-dinitrobenzoyl)-(R)-phenylglycinol to silica gel through carbamate linkage. The CSP was applied in resolving racemic N-acyl-1-arylaminoalkanes and the chromatographic resolution results were compared with those on the previously reported CSP (CSP 1) derived from N-(3,5-dinitrobenzoyl)-(2S,3R)-norephedrine. From the comparison of the resolution results on CSP 1 and CSP 2, it was concluded that CSP 2 is more effective than CSP 1 in the resolution of racemic N-acyl-1-arylaminoalkanes.

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