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Resolution of enantiomers of the antiarrhythmic drug encainide and its major metabolites by chiral derivatization and high-performance liquid chromatography

โœ Scribed by Chandra Prakash; Hemant K. Jajoo; Ian A. Blair; Robert F. Mayol


Book ID
108449363
Publisher
Elsevier Science
Year
1989
Weight
693 KB
Volume
493
Category
Article
ISSN
0378-4347

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Determination of encainide and its metab
โœ K. Selinger; J.C. Crawhall ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 331 KB

Encainide (ENC) and its metabolites O-demethylencainide (ODE), 3-methoxy-O-demethylencainide (MODE), N-demethylencainide (NDE) and bis-N,O-demethylencainide (NODE) have been measured by two HPLC procedures. The method of Mayol using a mu Porasil column with ethanol-water-methanesulphonic acid as mob