Chiral separation of the enantiomers of metoprolol and its metabolites by high performance liquid chromatography
โ Scribed by Kyeong Ho Kim; Sang Duk Shin; Joo Hyun Lee; Sang Cheal Lee; Jong-Seong Kang; Woongchon Mar; Seon-Pyo Hong; Hyun Ju Kim
- Book ID
- 105672473
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 593 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0253-6269
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๐ SIMILAR VOLUMES
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## Abstract A direct HPLC method for chiral separation of dorzolamide hydrochloride (4__S__,6__S__) and its enantiomer (4__R__,6__R__) was developed. Dorzolamide (4__S__,6__S__) and its antipode were separated on a chiralโฮฑ~1~โacid glycoprotein column (150ร4.0โmm, 5โฮผm). The influences of pH, tempe