Resolution of 1-phenoxy-, 1-phenylmethoxy- and 1-(2-phenylethoxy)-2-propanol and their butanoates by hydrolysis with lipase B from Candida antarctica
✍ Scribed by Bård H. Hoff; Viggo Waagen; Thorleif Anthonsen
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 368 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0957-4166
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📜 SIMILAR VOLUMES
Lipase B from Candida antarctica (CAL-B) catalyses the highly enantioselective (E > 200) transesterification of some 1-biaryl-2-yl-, -3-yl-, and -4-ylethanols and -propan-1-ols, as well as 1-(o-, m-, and p-pyridylphenyl)ethanols, 6, with vinyl acetate, Kazlauskas rule being obeyed in all cases. meta
Enantiomerically pure (R)-l-phenylethylamine and ethyl rac-2methyloctanoate in the presence of lipase from Candidada antarctica (Novozym 435) reacted to give (R)-2-methyloctanoic (R)-l-phenylethylamide as the predominant diastereomer of 30 -40% de at = 100% conversion. Ethyl rac-2-methyldecanoate an