Optical resolution of racemic N-benzyloxycarbonyl-protected alpha-alkoxyglycines, (+/-)-Cbz-Gly(OR)-OH (R = Et and Pr(i)), was achieved by means of fractional crystallization of diastereomeric salts with (+)-(1S,2S)-2-amino-1-phenyl-1,3-propanediol or diastereomeric esters of (+)- or (-)-menthol. Th
Resolution and absolute configuration of (+)-α-anilinopropionic acid
✍ Scribed by Philip S. Portoghese
- Publisher
- John Wiley and Sons
- Year
- 1964
- Tongue
- English
- Weight
- 171 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0022-3549
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Treatment of the bridged oxepine (±)-1 with a large excess epoxides (±)-5 and (±)-6. The resolution of the hydroazulenone (±)-2 is achieved by fractional crystallization of of powdered sodium methoxide in Et 2 O or with triphenylphosphonium methylide leads to the functionalized the quinine salt (؊)-
## Abstract The __trans__ isomer of 2,7‐di‐__tert__‐butylnaphtho[1,8‐__cd__][1,2]dithiole 1,2‐dioxide, a __vic__‐disulfoxide of the highest thermal stability reported to date, has been resolved into its enantiomers by preparative chiral liquid chromatography. This represents the first resolution ac