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Resolution, absolute stereochemistry and molecular pharmacology of the enantiomers of ATPA

✍ Scribed by Tine B Stensbøl; Lars Borre; Tommy N Johansen; Jan Egebjerg; Ulf Madsen; Bjarke Ebert; Povl Krogsgaard-Larsen

Book ID
114017444
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
219 KB
Volume
380
Category
Article
ISSN
0014-2999

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✍ Karla Frydenvang; Jan J. Hansen; Dr. Povl Krogsgaard-Larsen; Ann Mitrovic; Hue T 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 535 KB

## Abstract Phaclofen, which is the phosphonic acid analogue of the GABA~B~ agonist (RS)‐3‐(4‐chlorophenyl)‐4‐aminobutyric acid (baclofen), is a GABA~B~ antagonist. As part of our studies on the structural requirements for activation and blockade of GABA~B~ receptors, we have resolved phaclofen usi