Resistance to the mitotic inhibitor NY 3170 in Chinese hamster ovary cells
โ Scribed by WARR, J; ADAMS, K; ANDERSON, M; BREWER, F
- Book ID
- 122290211
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 372 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0309-1651
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Isolation and characterization of Chinese hamster ovary cell mutants resistant to different DNA polymerase inhibitors (aphidicolin, ara-A and ara-C) have been described. A particular mutant (JK3-1-2A) characterized in detail was found to grow and synthesize DNA in medium containing an amount of aphi
Genetic characterizations of the Chinese hamster ovary cell mutants resistant to the DNA polymerase inhibitors (aphidicolin, ara-A and ara-C) have been described. Resistance to all three inhibitors showed dominance among the progeny of somatic cell crosses between the wild type and mutant parents. A
## Abstract We have previously shown that very high levels of hypersensitivity to several resistance modifiers are correlated with increasing multidrug resistance in a series of Chinese hamster ovary cell lines. We have now selected a new member of the series which is an exception to this correlati