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Resistance to pactamycin in clones of Streptomyces lividans containing DNA from pactamycin-producing Streptomyces pactum

โœ Scribed by Calcutt, Michael J.; Cundliffe, Eric

Book ID
122053566
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
543 KB
Volume
93
Category
Article
ISSN
0378-1119

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Methylation of 16S ribosomal RNA and res
Methylation of 16S ribosomal RNA and resistance to aminoglycoside antibiotics in clones of Streptomyces lividans carrying DNA from Streptomyces tenjimariensis
โœ Skeggs, Patricia A. ;Thompson, Jill ;Cundliffe, Eric ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› Springer ๐ŸŒ English โš– 914 KB

A single gene from Streptomyces tenjimariensis, conferring resistance to kanamycin, apramycin and sisomicin, has been cloned in Streptomyces lividans. The mechanism of resistance involves methylation of 16S RNA in the 30S ribosomal subunit.