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Methylation of 16S ribosomal RNA and resistance to aminoglycoside antibiotics in clones of Streptomyces lividans carrying DNA from Streptomyces tenjimariensis

✍ Scribed by Skeggs, Patricia A. ;Thompson, Jill ;Cundliffe, Eric

Book ID
104770469
Publisher
Springer
Year
1985
Tongue
English
Weight
914 KB
Volume
200
Category
Article
ISSN
0026-8925

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✦ Synopsis

A single gene from Streptomyces tenjimariensis, conferring resistance to kanamycin, apramycin and sisomicin, has been cloned in Streptomyces lividans. The mechanism of resistance involves methylation of 16S RNA in the 30S ribosomal subunit.

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Involvement of 16S ribosomal RNA in resi
Involvement of 16S ribosomal RNA in resistance of the aminoglycoside-producers Streptomyces tenjimariensis, Streptomyces tenebrarius and Micromonospora purpurea
✍ Piendl, Wolfgang ;BΓΆck, August ;Cundliffe, Eric πŸ“‚ Article πŸ“… 1984 πŸ› Springer 🌐 English βš– 696 KB

Resistance to aminoglycoside antibiotics in Micromonospora purpurea (the producer of gentamicin C complex), Streptomyces tenebrarius (the nebramycin producer) and Streptomyces tenjimariensis (which makes istamycin) occurs at the level of the ribosome. Reconstitution analysis has revealed, in each ca

Methylation of 16S ribosomal RNA and res
Methylation of 16S ribosomal RNA and resistance to the aminoglycoside antibiotics gentamicin and kanamycin determined by DNA from the gentamicin-producer, Micromonospora purpurea
✍ Thompson, Jill ;Skeggs, Patricia A. ;Cundliffe, Eric πŸ“‚ Article πŸ“… 1985 πŸ› Springer 🌐 English βš– 598 KB

When DNA fragments from Micromonospora purpurea (the producer of gentamicin) were cloned in Streptomyces lividans, a gentamicin-resistant strain was obtained in which the ribosomes were highly resistant both to gentamicin and to kanamycin. Reconstitution analysis revealed that such resistance result