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Involvement of 16S ribosomal RNA in resistance of the aminoglycoside-producers Streptomyces tenjimariensis, Streptomyces tenebrarius and Micromonospora purpurea

✍ Scribed by Piendl, Wolfgang ;Böck, August ;Cundliffe, Eric

Book ID
104723809
Publisher
Springer
Year
1984
Tongue
English
Weight
696 KB
Volume
197
Category
Article
ISSN
0026-8925

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✦ Synopsis

Resistance to aminoglycoside antibiotics in Micromonospora purpurea (the producer of gentamicin C complex), Streptomyces tenebrarius (the nebramycin producer) and Streptomyces tenjimariensis (which makes istamycin) occurs at the level of the ribosome. Reconstitution analysis has revealed, in each case, that 16S rRNA plays a critical role in determining such resistance.

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Methylation of 16S ribosomal RNA and res
Methylation of 16S ribosomal RNA and resistance to aminoglycoside antibiotics in clones of Streptomyces lividans carrying DNA from Streptomyces tenjimariensis
✍ Skeggs, Patricia A. ;Thompson, Jill ;Cundliffe, Eric 📂 Article 📅 1985 🏛 Springer 🌐 English ⚖ 914 KB

A single gene from Streptomyces tenjimariensis, conferring resistance to kanamycin, apramycin and sisomicin, has been cloned in Streptomyces lividans. The mechanism of resistance involves methylation of 16S RNA in the 30S ribosomal subunit.

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Methylation of 16S ribosomal RNA and resistance to the aminoglycoside antibiotics gentamicin and kanamycin determined by DNA from the gentamicin-producer, Micromonospora purpurea
✍ Thompson, Jill ;Skeggs, Patricia A. ;Cundliffe, Eric 📂 Article 📅 1985 🏛 Springer 🌐 English ⚖ 598 KB

When DNA fragments from Micromonospora purpurea (the producer of gentamicin) were cloned in Streptomyces lividans, a gentamicin-resistant strain was obtained in which the ribosomes were highly resistant both to gentamicin and to kanamycin. Reconstitution analysis revealed that such resistance result