## Abstract Cancer cells that develop resistance to chemotherapeutic agents are a major clinical obstacle in the successful treatment of breast cancer. Acquired cancer chemoresistance is a multifactorial phenomenon, involving various mechanisms and processes. Recent studies suggest that chemoresist
โฆ LIBER โฆ
Resistance to hydrogen peroxide associated with altered catalase mRNA stability in MCF7 breast cancer cells
โ Scribed by Steven A. Akman; Gerald Forrest; F.-F. Chu; James H. Doroshow
- Book ID
- 119119761
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 1013 KB
- Volume
- 1009
- Category
- Article
- ISSN
- 0167-4781
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Annamycin (Ann) is a highly lipophilic anthracycline antibiotic that has been shown to circumvent MDR-1 both in vitro and in vivo. A liposomal formulation of Ann is currently in phase I clinical trials. The multidrug resistance-associated protein (MRP) has been found to be over-expressed in some hum