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Down-regulation of Raf-1 kinase is associated with paclitaxel resistance in human breast cancer MCF-7/Adr cells

โœ Scribed by Michael Lee; Woo Suk Koh; Sang Seop Han


Book ID
117467681
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
209 KB
Volume
193
Category
Article
ISSN
0304-3835

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Recent studies have shown that high levels of the apoptosisrelated proteins bcl-2 and bcl-x, increase, while over-expression of bcl-x, or bax decreases, resistance to drugs that induce apoptosis in some human cancer cells. In the present report, we investigated whether expression of these apoptosis-