The ErbB receptor tyrosine kinase family consists of the epidermal growth factor (EGF) receptor (ErbB1) and three related receptors (ErbB2, ErbB3, ErbB4). Their intrinsic tyrosine kinases can be activated by receptor-dimerization induced by numerous ligands or overexpression. ErbB receptors are freq
Resistance of MCF7 human breast carcinoma cells to TNF-induced cell death is associated with loss of p53 function
✍ Scribed by Cai, Zhenzi; Capoulade, Corinne; Moyret-Lalle, Caroline; Amor-Gueret, Mounira; Feunteun, Jean; Larsen, Annette K; Paillerets, Brigitte Bressac-de; Chouaib, Salem
- Book ID
- 110061020
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 271 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Human breast cancer MCF‐7 cells, growth‐arrested by serum starvation, were stimulated with recombinant human insulinlike growth factor‐1 (IGF‐I). An increase in DNA synthesis was induced 20 hr later, which was as effective as that induced by serum. The increase in DNA synthesis was sign
## Abstract Compared to proliferating keratinocytes (KCs), growth‐arrested KCs are relatively resistant to UV‐light induced apoptosis. When KCs undergo confluency, or following exposure to anti‐proliferative agents such as IFN‐γ plus a phorbol ester–12‐__O__‐tetradecanoylyphorbol‐13‐acetate (TPA),