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Resistance of human nucleotide excision repair synthesis in vitro to p21Cdn1

✍ Scribed by Shivji, Mahmud KK; Ferrari, Elena; Ball, Kathryn; Hübscher, Ulrich; Wood, Richard D

Book ID: 110061808
Publisher: Nature Publishing Group
Year: 1998
Tongue: English
Weight: 549 KB
Volume: 17
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1202352

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## Abstract Induction of the p21^WAF1^ protein (hereafter called p21) following genotoxic stress is known to inhibit proliferating cell nuclear antigen (PCNA)‐dependent DNA repair, downregulate apoptosis, and trigger a sustained growth‐arrested phenotype called accelerated senescence. Studies with