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p21waf1/cip1-null human fibroblasts are deficient in nucleotide excision repair downstream the recruitment of PCNA to DNA repair sites

✍ Scribed by Stivala, Lucia A; Riva, Federica; Cazzalini, Ornella; Savio, Monica; Prosperi, Ennio


Book ID
110064434
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
233 KB
Volume
20
Category
Article
ISSN
0950-9232

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## Abstract Induction of the p21^WAF1^ protein (hereafter called p21) following genotoxic stress is known to inhibit proliferating cell nuclear antigen (PCNA)‐dependent DNA repair, downregulate apoptosis, and trigger a sustained growth‐arrested phenotype called accelerated senescence. Studies with