Resistance of hepatitis B to antiviral agents
β Scribed by Karl P. Fischer
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 19 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0270-9139
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We aimed to determine the antiviral activity and safety of a new nucleotide analogue, LB80380, in chronic hepatitis B (CHB) patients with lamivudine-resistant virus. Sixty-five patients with lamivudine-resistant virus were randomized to receive five ascending daily doses (30, 60, 90, 150, 240 mg) of
## Abstract Serial monotherapy and addβon regimes for treatment of chronic hepatitis B virus (HBV) infection may induce the accumulation of viral resistance mutations in patients, reducing the options for ongoing viral suppression. The induction of antiviral resistance by serial application of poly
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