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Resin-bound aminothiols: synthesis and application

✍ Scribed by Spyros Mourtas; Christina Katakalou; Andriana Nicolettou; Chryssoula Tzavara; Dimitrios Gatos; Kleomenis Barlos

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 249 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)02445-0

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✦ Synopsis

Aminothiols were attached through their thiol group onto the 4,4%-dimethoxytrityl (Dmt)-, 4-methoxytrityl (Mmt)-, 4-methyltrityl (Mtt)-, trityl (Trt)-and 2-chlorotrityl (Clt)-resins. The new resins were used in the solid-phase synthesis of aminothiol containing peptides utilizing N-Fmoc amino acids. The synthesized peptides were cleaved from the resins by treatment with trifluoroacetic acid (TFA) solutions using triethylsilane (TES) or ethanedithiol (EDT) as scavengers.

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