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Residues affecting the catalysis and inhibition of rat lens aldose reductase

✍ Scribed by Deborah A. Carper; Thomas C. Hohman; Susan E. Old

Book ID
113269266
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
961 KB
Volume
1246
Category
Article
ISSN
0167-4838

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The catalytic and inhibitory profiles of xylose reductase isolated from the yeast Pachysolen tanno- philus (PTXR) are compared to those of aldose reductase (AR) obtained form rat lens. While both PTXR and rat lens AR are NADPH-specific enzymes and have an affinity for a variety of substrates such as