Reserpine induced intraneuronal dopamine oxidation: reversal by MPP+ action
โ Scribed by S.P. Bagchi
- Book ID
- 118344957
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 407 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0024-3205
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๐ SIMILAR VOLUMES
## Abstract To gain insight into the antiparkinsonian effects of selective D1 and D2 dopamine receptor stimulation, we examined the ability of D1 (SKF 38393) and D2 (quinpirole) agonists to reverse catalepsy induced by the combined administration of reserpine and ฮฑโmethylโpโtyrosine (AMPT) in rats.
Accumulating evidence suggests that endogenous dopamine may act as a neurotoxin and thereby participate in the pathophysiology of Parkinsonโs disease (PD). Cyclooxygenase-2 (COX-2) has been implicated in the pathogenesis of PD due to its ability to generate reactive oxygen species (ROS). Inhibition