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Requirement of leukemia inhibitory factor for establishing and maintaining embryonic stem cells in mice

✍ Scribed by Jae Hee Lee; Eun Ju Lee; Chae Hyun Lee; Jun Hong Park; Jae Yong Han; Jeong Mook Lim

Book ID
116473675
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
446 KB
Volume
92
Category
Article
ISSN
1556-5653

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## Abstract Self‐renewal of __in vitro__ cultured mouse embryonic stem (mES) cells is dependent on the presence of leukemia inhibitory factor (LIF). LIF induces overexpression and tyrosine phosphorylation of STAT3 (signal transducer and activator of transcription 3) and its subsequent nuclear trans