Certain types of human papillomavirus (HPV), such as types 16 and 18, are etiological agents for carcinogenesis of the uterine cervix. These HPVs have two oncogenes, E6 and E7, that have transforming activities in established murine cells. Tumorigenicity and decreased serum requirement for cell grow
Requirement of e6ap and the features of human papillomavirus e6 necessary to support degradation of p53
β Scribed by Brooke Cooper; Steven Schneider; Joanna Bohl; Yong-hui Jiang; Arthur Beaudet; Scott Vande Pol
- Book ID
- 114092951
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 607 KB
- Volume
- 306
- Category
- Article
- ISSN
- 0042-6822
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The oncogenic human papillomaviruses (HPVs) are able to efficiently target p53 for degradation by the ubiquitin pathway. We previously demonstrated inefficient HPV E6-mediated degradation and resulting high steady-state levels of p53 in cell hybrids between a peripheral neuroepithelioma cell line an
The E6 protein of cancer-associated human papillomavirus type 16 (HPV16) binds to cellular p53 and promotes its degradation through the ubiquitin pathway. In an attempt to identify the regions of E6 that could be targetted for functional inhibition, we generated monoclonal antibodies to the HPV16 E6