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Reproducibility of MR perfusion and 1H spectroscopy of bone marrow

✍ Scribed by James F. Griffith; David K.W. Yeung; Steven K.K. Chow; Jason Chi Shun Leung; Ping Chung Leung

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
210 KB
Volume
29
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Purpose

To determine the reproducibility of proton (^1^H) magnetic resonance (MR) spectroscopy and dynamic contrast‐enhanced MR imaging in a clinical setting for the assessment of marrow fat fraction and marrow perfusion in longitudinal studies.

Materials and Methods

In all, 36 subjects (17 females, 19 males, mean age 72.9 ± 2.9 years) who underwent MR spectroscopy and/or dynamic contrast‐enhanced perfusion imaging of the proximal femur were asked to return after 1 week for a repeat MR examination.

Results

Reproducibility of ^1^H MR spectroscopy in all bone areas tested was high, ranging from 0.78–0.85, with the highest reproducibility being in the femoral head and lowest in the femoral neck. Reproducibility of paired perfusion measurements ranged from 0.59 (enhancement slope femoral head) to 0.98 (enhancement maximum acetabulum). Overall reproducibility of ^1^H MR spectroscopy and dynamic contrast‐enhanced imaging tended to be best in areas with the highest inherent fat fraction or perfusion.

Conclusion

Reproducibility of ^1^H MR spectroscopy or perfusion imaging is sufficiently high to warrant these techniques being applied to the longitudinal study of bone diseases. J. Magn. Reson. Imaging 2009;29:1438–1442. © 2009 Wiley‐Liss, Inc.

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