Studies of hepatitis B virus (HBV) mutants have been hampered by the lack of a small animal model with long-term infection of cloned HBV. Using a mouse model in which liver cells were highly replaced with human hepatocytes that survived over a long time with mature human hepatocyte function, we perf
Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus
✍ Scribed by Maura Dandri; Martin R. Burda; Eva Török; Joerg M. Pollok; Alicja Iwanska; Gunhild Sommer; Xavier Rogiers; Charles E. Rogler; Sanjeev Gupta; Hans Will; Heiner Greten; Joerg Petersen
- Book ID
- 111721461
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 370 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0270-9139
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## Abstract Studies of hepatitis B virus (HBV) infection in non‐human primates such as chimpanzees are no longer possible due to ethical considerations and the endangered status of chimpanzees since April 2007 in Japan. A human hepatocyte transplanted chimeric mouse was used to characterize HBV inf