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Reply to letter to the editor of Jean-Pierre Fryns ? ?on the nosology of severe acrofacial dysostosis with limb deficiency?

โœ Scribed by Oostra, Roelof Jan; Baljet, Bob; Hennekam, Raoul C.M.


Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
2 KB
Volume
82
Category
Article
ISSN
0148-7299
DOI
10.1002/(sici)1096-8628(19990129)82:3<283::aid-ajmg17>3.0.co;2-1

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In this journal, Oostra et al. [1998] reported on the distinct MCA syndrome in a plaster cast of a presumably term newborn female with macrocephaly, midface hypoplasia, short upper lip, macrostomia secondary to bilateral orofacial clefting, low-set small malformed ears, micrognathia, severe hypoplas

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The comments of Frost are quite appropriate relative to our case report. The in utero fractures were apparently of different ages and were healing in a reasonable fashion. The fact that no fractures occurred during delivery or the few months that the infant survived speaks again of an intrinsic defe

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We would like to thank Dr. Botto et al. for their response to my Letter to the Editor [Froster, 1996]. I did not intend to imply that Botto et al. [1996] misclassified limb deficiencies. My intention was simply to point out that there are differences in the classification of limb defects. It is co