Reply to 'Haplotype block structure of the cytochrome P450 CYP2C gene cluster on chromosome 10'
โ Scribed by Ahmadi, Kourosh R; Weale, Michael E; Roses, Allen D; Saunders, Ann M; Goldstein, David B
- Book ID
- 109916812
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 74 KB
- Volume
- 37
- Category
- Article
- ISSN
- 1061-4036
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๐ SIMILAR VOLUMES
Cytochrome P450 genes from the CYP2A, CYP2B, and C Y P 2 F subfamilies form a tight cluster which we have localized on the detailed physical map of human chromosome 19. The corresponding three gene subfamilies are also clustered in the mouse genome, on the region of chromosome 7 known to be syntenic
We have studied the genetic linkage of two markers, the apolipoprotein C1 (APOC1) gene and a cytochrome P450 (CYP2A) gene, in relation to the gene for myotonic dystrophy (DM). A peak lod score of 9.29 at 2 cM was observed for APOC1-DM, with a lod score of 8.55 at 4 cM for CYP2A-DM. These two markers