Reply: mixed germ cell sex cord-stromal tumors of the testis and ovary
β Scribed by Thomas M. Ulbright; Robert H. Young
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 48 KB
- Volume
- 450
- Category
- Article
- ISSN
- 1432-2307
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We report the cytogenetic findings in a case of mixed germ cell-sex cord-stromal tumor of the ovary in a 5-month-old girl. Monosomy 22 was observed as the sole karyotypic abnormality. This result was confirmed by comparative genomic hybridization, which revealed no additional chromosomal imbalances.
Malignant ovarian germ cell tumors (OGCT) and sex cord stromal tumors (SCST) are much less common than epithelial ovarian cancer, each accounting for less than 5% of all ovarian malignancies. The combination of vincristine, dactinomycin, and cyclophosphamide (VAC) became the standard chemotherapy fo