Replication linkage study for prostate cancer susceptibility genes

✍ Scribed by Brian K. Suarez; Jennifer Lin; John S. Witte; David V. Conti; Martin I. Resnick; Eric A. Klein; James K. Burmester; David A. Vaske; Tarit K. Banerjee; William J. Catalona

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 279 KB
• Volume: 45
• Category: Article
• ISSN: 0270-4137
• DOI: 10.1002/1097-0045(20001001)45:2<106::aid-pros4>3.0.co;2-h

✦ Synopsis

Since the publication of the first genome screen for prostate cancer (CaP) 5 years ago, over a dozen linkage studies have appeared. Most attention has been directed to chromosome 1, where two separate regions have been identified as harboring a prostate cancer susceptibility locus: HPC1 in the 1q24-25 interval and PCaP in the 1q42.2-43 interval. Linkage analysis of chromosome 16 has also provided evidence of harboring two loci predisposing to CaP. METHODS. We report on a replication linkage study of chromosomes 1 and 16 in 45 new and 4 expanded multiplex CaP families. Multipoint Z-scores were obtained for 30 highly polymorphic short-sequence tandem repeat markers spanning chromosome 1, and 22 markers spanning chromosome 16. RESULTS. The replication sample gave no evidence for a CaP susceptibility locus in the 1q24-25 interval and equivocal evidence for such a locus at 1q42.2-43. With respect to chromosome 16, positive Z-scores were obtained over a contiguous interval covering the entire p arm and the proximal half of the q arm. CONCLUSIONS. The linkage analysis of our replication sample does not support the existence of HPC1, and the evidence for the existence of PCaP remains equivocal.