Replication licensing and cancer — a fatal entanglement?
✍ Scribed by Blow, J. Julian; Gillespie, Peter J.
- Book ID
- 109948187
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 423 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1474-1776
- DOI
- 10.1038/nrc2500
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📜 SIMILAR VOLUMES
To maintain genome integrity in eukaryotes, DNA must be duplicated precisely once before cell division occurs. A process called replication licensing ensures that chromosomes are replicated only once per cell cycle. Its control has been uncovered by the discovery of the CDKs (cyclin dependent kinase
## Abstract To prevent duplicate DNA synthesis, metazoan replication origins are licensed during G1. Only licensed origins can initiate replication, and the cytoplasm interacts with the nucleus to inhibit new licensing during S phase. DNA replication in the mammalian one‐cell embryo is unique becau