To maintain genome integrity in eukaryotes, DNA must be duplicated precisely once before cell division occurs. A process called replication licensing ensures that chromosomes are replicated only once per cell cycle. Its control has been uncovered by the discovery of the CDKs (cyclin dependent kinase
β¦ LIBER β¦
Cells and prions: A license to replicate
β Scribed by Mario Nuvolone; Adriano Aguzzi; Mathias Heikenwalder
- Book ID
- 113621432
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 506 KB
- Volume
- 583
- Category
- Article
- ISSN
- 0014-5793
No coin nor oath required. For personal study only.
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## Abstract To prevent duplicate DNA synthesis, metazoan replication origins are licensed during G1. Only licensed origins can initiate replication, and the cytoplasm interacts with the nucleus to inhibit new licensing during S phase. DNA replication in the mammalian oneβcell embryo is unique becau