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Replication-induced protein synthesis and its importance to proteomics

✍ Scribed by Ian Humphery-Smith


Book ID
101317552
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
117 KB
Volume
20
Category
Article
ISSN
0173-0835

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The kinetics of non-histone chromosomal protein (NHCP) synthesis were studied in Chinese hamster ovary (CHO) plateau phase cells stimulated to proliferate and were compared to NHCP synthesis kinetics in two populations of synchronous G1 traversing cells. In all cases, NHCP synthesis rates increase 3

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With the aid of a kinetic model, we have investigated how the adaptation between the various components of the tRNA cycle and the codon frequencies affects the rate of protein synthesis. Depending on the relative amounts of total tRNA, synthetase and ribosomes, the optimal correlations vary between