Optimum biased-coin designs for sequenti
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Anthony C. Atkinson
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Article
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1999
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John Wiley and Sons
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English
โ 121 KB
Randomized optimum designs of biased-coin type are compared with other strategies for the sequential allocation of two or more treatments in a clinical trial. The emphasis is on the variance of estimated treatment contrasts. This variance, which depends on the design strategy employed, may be interp