✦ LIBER ✦
Optimum biased-coin designs for sequential treatment allocation with covariate information
✍ Scribed by Anthony C. Atkinson
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 121 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0277-6715
No coin nor oath required. For personal study only.
✦ Synopsis
Randomized optimum designs of biased-coin type are compared with other strategies for the sequential allocation of two or more treatments in a clinical trial. The emphasis is on the variance of estimated treatment contrasts. This variance, which depends on the design strategy employed, may be interpreted as the number of patients on whom information is lost. Simulations provide clear plots of the evolution of this loss during the course of the clinical trial.