## Abstract Success of immunotherapy with dendritic cells (DC) to treat cancer is highly dependent on their interaction with and activation of antigen specific T cells. To maximize DC–T cell contact accurate delivery of the therapeutic cells into the lymph node, or efficient trafficking of DC to th
Repeatability of a novel technique for in vivo measurement of three-dimensional patellar tracking using magnetic resonance imaging
✍ Scribed by Robert A. Fellows; Nick A. Hill; Norma J. MacIntyre; Mark M. Harrison; Randy E. Ellis; David R. Wilson
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 453 KB
- Volume
- 22
- Category
- Article
- ISSN
- 1053-1807
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Purpose
To determine the repeatability of a novel noninvasive MRI‐based technique for measuring patellofemoral kinematics in vivo.
Materials and Methods
The patellar kinematics measurement method relies on registering bone models (with associated coordinate systems) developed from a high resolution MRI scan to loaded bone positions derived from fast, low resolution MRI scans. The intrasubject variability, high resolution to low resolution registration error, and interexperimenter repeatability were quantified in experiments on three healthy subjects.
Results
The intrasubject variability and registration error were within range of the accuracy of our procedure; specifically, less than or equal to 1.40° for orientation and 0.81 mm for translation. The interexperimenter repeatability was less than or equal to 1.28° for orientation, with the exception of patellar spin, and 0.68 mm for translation.
Conclusion
Our novel measurement technique can measure three‐dimensional patellar tracking noninvasively during loaded flexion in a repeatable manner. Our results compare well to another noninvasive tracking protocol, fast phase‐contrast MRI, which has a reported subject interexam variability of 2.4° or less for patellar orientation. A particular strength of our method is that axes and high‐resolution bone models need only be determined once for intrasubject comparisons. The method is sufficiently accurate and repeatable to detect clinically significant changes in patellofemoral kinematics. J. Magn. Reson. Imaging 2005;22:145–153. © 2005 Wiley‐Liss, Inc.
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