Reorientational dynamics, hydrogen bonding and hydrophilicity of X-ray contrast agents in solution

✍ Scribed by Michael van de Bruck; Andreas Dölle; Günter Michl; Bernd Radüchel

• Book ID: 102527997
• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 119 KB
• Volume: 39
• Category: Article
• ISSN: 0749-1581
• DOI: 10.1002/mrc.936

✦ Synopsis

In order to probe the hydrophilic and lipophilic properties of iodinated X-ray contrast agents, a new parameter was introduced, the relative reduced molecular correlation time of reorientational motion. Therefore, the viscosities and 13 C spin-lattice relaxation times of the five contrast agents iopromide, iohexol, iopamidol, iotetrol and N-acetyliotetrol in their solutions with dimethylsulfoxide, water and methanol were measured. From these data the relative reduced molecular correlation times were evaluated, and a relation between these correlation times and measured water/butanol partition coefficients [log(P) values] could be established. The order for the relative reduced molecular correlation times is: iopromide > iopamidol > iohexol > N-acetyliotetrol > iotetrol. When subdividing the contrast agents into classes of structurally similar compounds, the same order was observed for the log(P) values, namely iopromide > iopamidol > iohexol.