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RENAL UPTAKE AND NEPHROTOXICITY OF GENTAMICIN DURING URINARY ALKALINIZATION IN RATS

โœ Scribed by P. J. S. Chiu; G. H. Miller; J. F. Long; J. A. Waitz

Book ID
108932891
Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
565 KB
Volume
6
Category
Article
ISSN
0305-1870

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๐Ÿ“œ SIMILAR VOLUMES

Age-dependent nephrotoxicity and the pha
Age-dependent nephrotoxicity and the pharmacokinetics of gentamicin in rats
โœ R. Marre; N. Tarara; T. Louton; K. Sack ๐Ÿ“‚ Article ๐Ÿ“… 1980 ๐Ÿ› Springer ๐ŸŒ English โš– 410 KB

The pharmacokinetics and nephrotoxicity of gentamicin were studied in female Wistar rats of different ages. I.m. administration of 5 mg of gentamicin/kg revealed that young rats (90g) had lower peak serum levels and a prolonged elimination half-life, when compared with adult animals. After repeated