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Renal irradiation and the pharmacology and toxicity of methotrexate and cisplatinum

✍ Scribed by John E. Moulder; John S. Holcenberg; Barton A. Kamen; Mary Cheng; Brian L. Fish

Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
443 KB
Volume
12
Category
Article
ISSN
0360-3016

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## Abstract Methotrexate (MTX), a potent folate antagonist by virtue of its ability to inhibit the enzyme dihydrofolate reductase [1], continues to be a useful cancer chemotherapeutic agent [2]. Information not only on its mechanism of action, but also its pharmacology has led to improved dosage sc