Renal handling of biphosphonate alendron
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Ichiro Kino; Yukio Kato; Jiunn H. Lin; Yuichi Sugiyama
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Article
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1999
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John Wiley and Sons
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English
β 134 KB
Alendronate is a bisphosphonate that is secreted via a saturable pathway in rat kidney. This study is designed to discover if the rate-determining step in its net renal secretion is uptake into the renal tubule. The tissue uptake clearance of alendronate by the kidney, estimated from an integration