Renal handling of biphosphonate alendron
โ
Ichiro Kino; Yukio Kato; Jiunn H. Lin; Yuichi Sugiyama
๐
Article
๐
1999
๐
John Wiley and Sons
๐
English
โ 134 KB
Alendronate is a bisphosphonate that is secreted via a saturable pathway in rat kidney. This study is designed to discover if the rate-determining step in its net renal secretion is uptake into the renal tubule. The tissue uptake clearance of alendronate by the kidney, estimated from an integration