𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Renal handling of 2-methyl-4-chlorophenoxyacetic acid (MCPA) in rats

✍ Scribed by Helmut Bräunlich; Heike Bernhardt; Ingo Bernhardt

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
379 KB
Volume
9
Category
Article
ISSN
0260-437X

No coin nor oath required. For personal study only.

✦ Synopsis

Following i.p. administration of various doses of 2-methyl-4-chlorophenoxyacetic acid (MCPA), ca. 50% is excreted during a 5-h diuresis experiment. After i.p. administration of MCPA, virtually no distribution occurs (Vre, = 18% of the body weight). Renal excretion of MCPA can be accelerated by inhibition of its renal tubular reabsorption. The distinct inhibition of renal excretion of MCPA by simultaneous administration of probenecid or paminohippurate (PAH) indicates the active tubular transport of MCPA; this transport process can be stimulated by treatment of rats with triiodothyronine. Active tubular transport of MCPA was confirmed by measurement of MCPA accumulation in renal cortical slices, both under aerobic and anaerobic conditions. Accumulation of MCPA under anaerobic conditions indicates an additional passive uptake and binding of MCPA in kidney tissue in accordance with the high degree of binding to plasma albumin (85%).

📜 SIMILAR VOLUMES

Studies on the renal transport of trimet
Studies on the renal transport of trimethylpentanoic acid metabolites of 2,2,4-trimethylpentane in rat renal cortical slices
✍ Edward A. Lock; Josef Strasser Jr.; James S. Bus; Michel Charbonneau 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 452 KB

acid; effect on renal transport of organic anions; effect on renal transport of organic cations. 2,2,4-Trimethylpentane (TMP), a nephrotoxic component of unleaded gasoline in male but not female rats, undergoes oxidative metabolism to yield 2,2,4-and 2,4,4-trimethylpentanol, pentanoic acid and 5hyd

Increased intensity of tert -butoxyl rad
Increased intensity of tert -butoxyl radical emission in 4-chloro-2-methylphenoxyacetic acid (MCPA) synthesis
✍ Jezierski, Adam; Zakrzewski, Jerzy; Moszczyński, Wiesław 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 86 KB

The important herbicide, 2-methyl-4-chlorophenoxyacetic acid (MCPA) was synthesized by the chlorination of 2-methylphenoxyacetic acid with tert-butyl hypochlorite in the presence of methyl N,N-dimethylglycinate as a catalyst, giving a high yield and regioselectivity. The reaction was investigated us

GC-MS separation and quantitation of 3-c
GC-MS separation and quantitation of 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid and hippuric acid from plasma of patients with renal failure: Application to blood purification methods
✍ Liebich, Hartmut M. ;Reichenmiller, Anna-Maria ;Wahl, Hans-Günther ;Tetschner, B 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 349 KB

## Abstract Solid‐phase extraction, capillary GC, and mass selective detection have been used to determine 3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropionic acid (furanpropionic acid) and hippuric acid in the plasma of patients with chronic renal failure. The concentrations of furanpropionic acid and hi

Mutagenicity and cytotoxicity of n-methy
Mutagenicity and cytotoxicity of n-methyl-2-pyrrolidinone and 4-(methylamino)butanoic acid in the Salmonella/microsome assay
✍ David A. Wells; Harvey F. Thomas; George A. Digenis 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 482 KB

The industrial solvent N-methyl-2-pyrrolidinone (NMP) and its hydrolysis product, 4-(methylamino)butanoic acid (N-MeGABA), were examined for mutagenicity and cytotoxicity in the Ames Salmonella/microsome assay. In order to detect a broad range of possible mutagenic endpoints, the following strains w