GC-MS separation and quantitation of 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid and hippuric acid from plasma of patients with renal failure: Application to blood purification methods
✍ Scribed by Liebich, Hartmut M. ;Reichenmiller, Anna-Maria ;Wahl, Hans-Günther ;Tetschner, Birgid ;Risler, Teut ;Eggstein, Manfred ;Quellhorst, Eduard
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 349 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0935-6304
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✦ Synopsis
Abstract
Solid‐phase extraction, capillary GC, and mass selective detection have been used to determine 3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropionic acid (furanpropionic acid) and hippuric acid in the plasma of patients with chronic renal failure. The concentrations of furanpropionic acid and hippuric acid were found to be highly elevated and reached levels of 4.56 ± 2.37 mg/dl (10 to 20‐fold higher than normal) and 12.90 ± 14.06 mg/dl (40 to 60‐fold), respectively. Treatment by hemodialysis and hemofiltration effectively eliminated hippuric acid (on average by 66 and 56%, respectively) but had little effect on furanpropionic acid. Intermittent peritoneal dialysis gave the best long‐term results. Both components were maintained at a lower level than by hemodialysis and hemofiltration.