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Renal effects of aluminium in uraemic rats and in rats with intact kidney function

✍ Scribed by H. Bräunlich; Ch. Fleck; L. Kersten; G. Stein; V. Laske; A. Müller; E. Keil

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
460 KB
Volume
6
Category
Article
ISSN
0260-437X

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✦ Synopsis

The effect on renal function following administration of aluminium (i.p., five times weekly (0.05 or 0.5 mg kg-1 body weight) for 12 weeks) to partially nephrectomized (5/6 NX) or intact female rats was examined. The observed loss of concentrating ability, characterized by increased urine volume and an increased sodium excretion, as well as increased renal excretion of p-aminohippurate (demonstrable after low-dose treatment with nephrotoxins) can be interpreted as an initiation of kidney function injury. No distinct differences in response were observed between partially nephrectomized and intact animals.

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